FROM STRUCTURAL STUDIES TO HCV VACCINE DESIGN

From Structural Studies to HCV Vaccine Design

Hepatitis C virus (HCV) is a serious and growing public health problem despite recent developments of antiviral therapeutics.To achieve global elimination of HCV, an effective cross-genotype vaccine is needed.The failure of previous vaccination trials to elicit an effective cross-reactive immune response demands better vaccine antigens to induce a

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Modeling the Spatial and Temporal Evolution of Stress during Multiworking Face Mining in Close Distance Coal Seams

Mining in close distance coal seams (CDCSs) is frequently associated with engineering disasters because of the complicated nature of stress distribution within CDCSs.In order to establish a layout of a roadway to minimize the occurrence of disasters associated with mining CDCS, here the spatial and temporal evolution of stress distribution during t

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Fiber-reinforced composites in fixed partial dentures

Fiber-reinforced composite resin (FRC) prostheses offer the advantages of good esthetics, minimal invasive treatment, and an ability to bond custom congratulations banner to the abutment teeth, thereby compensating for less-than-optimal abutment tooth retention and resistance form.These prostheses are composed of two types of composite materials: f

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